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Thursday, November 19, 2020

Narcotic Antagonists : Naloxone , Actions, Uses, Side effect.

 Narcotic Antagonists: Naloxone 


Opioid antagonists block ( or antagonize ) opiate-receptors sites, principal use is the treatment of opioid overdose. 


  • Reverse the opiate effects of narcotic overdose and respiratory depression 
Contraindications and precautions 

  • Patients who are using nonopioid drugs
  • Neonates and children 
  • Patients with a history of dependency; may precipitate acute withdrawal
Side Effects 

  • Too rapid reversal of narcotic depression-nausea, vomiting, tremors, hypertension 
  • Minimal pharmacologic effects in absence of narcotics 
  • Reversal of analgesia 
Nursing implications 

  • Preferred route of administration is intravenously; response is within 1 to 2 minutes, and peak action is within 20 to 60 minutes. 
  • Patient should be frequently assessed; if the narcotic analgesic lasts longer in the system than the action of the Narcan antagonist, then respiratory depression may recur.
  • If patient has a history of opioid dependency, administration of Nacran may produce symptoms of acute withdrawal.
  • If accidental poisoning or possible narcotic overdose is a concern, Narcon usually administered. 
  • Not effective against barbiturates or other central nervous system depressant medications. 

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